The Ugly-inator Ray was one of Doofenshmirtz's schemes and inventions. It harnessed the power of a toad to make anyone zapped by it ugly. Its use can be reversed by putting an object that is considered "beautiful" (such as a Picture of Vance Ward). Dr. Doofenshmirtz intended to fire it on all the handsome people in the Tri-State Area in order to make himself look handsome by comparison. ("The Best Lazy Day Ever")
- Perry the Platypus: Became ugly enough for Doofenshmirtz to laugh.
- Heinz Doofenshmirtz: No Effect.
- The Audience: Became a punk audience.
- Jeremy and the Incidentals: Became a Punk/Death Metal Band.
- Vance Ward: Went bald; clothes and suit were replaced with underwear and tank-top.
- Heinz's Big-Screen T.V.: Became an older 70's-style CRT TV.
- Heinz's Recliner: Became a Plastic Lawn Chair.
- Heinz's Balloon: (Used when the effects of the weapon were reversed) became cute & girly.